An 80-year-old woman in Japan has died with the coronavirus and become the country’s first recorded victim.
The death makes Japan just the third place outside of China to declare someone has died from the virus, along with Hong Kong and the Philippines.
At least 236 people have been officially diagnosed with the virus, now known as SARS-CoV-2, in Japan since its first infection on January 16.
Almost all of these, however – 219 at latest count – have been among passengers on a cruise ship which is quarantined in the water off a port near Yokohoma.
Health minister Katsunobu Kato confirmed the woman’s death today, February 13. She had been living in the Kanagawa region close to Tokyo.
Mr Kato said that authorities are not certain that the woman was killed by the virus, but that she is the first person to die after testing positive for the infection.
Paramedics in Japan are pictured driving an ambulance wearing hazmat suits. They are en route to a cruise ship which is moored at a port in Yokohoma and has had more than 200 infected patients
The 80-year-old woman’s death, near Tokyo, has become the 1,370th global fatality from the coronavirus. All but three deaths have been in mainland China
‘The relationship between the new coronavirus and the death of the person is still unclear,’ he said at a government briefing.
‘This is the first death of a person who tested positive.’
Further details about the woman have yet to emerge.
HOW THE CORONAVIRUS HAS SPREAD OVER TIME
The vast majority of coronavirus cases have been in mainland China, but more than 25 other countries and territories have declared infections:
- Belgium: 1 case, first case February 4
- Spain: 2 case, first case January 31
- Sweden: 1 case, first case January 31
- Russia: 2 cases, first case January 31
- UK: 9 cases, first case January 31
- India: 3 cases, first case January 30
- Philippines: 3 cases, first case January 30
- Italy: 3 cases, first case January 30
- Finland: 1 case, first case January 29
- United Arab Emirates: 8 cases, first case January 29
- Germany: 16 cases, first case Jan 27
- Sri Lanka: 1 case, first case Jan 27
- Cambodia: 1 case, first case Jan 27
- Canada: 7 cases, first case Jan 25
- Australia: 15 cases, first case Jan 25
- Malaysia: 18 cases, first case Jan 25
- France: 11 cases, first case January 24
- Nepal: 1 case, first case January 24
- Vietnam: 16 cases, first case Jan 24
- Singapore: 50 cases, first case January 23
- Macau: 10 cases, first case Jan 22
- Hong Kong: 51 cases, first case January 22
- Taiwan: 18 cases, first case Jan 21
- USA: 14 cases, first case January 20
- South Korea: 28 cases, first case January 20
- Japan: 236 cases, first case January 16
- Thailand: 33 cases, first case Jan 13
The Philippines was the first country outside of China to declare that somebody had died because of the coronavirus, on February 2.
A 44-year-old man there succumbed to ‘severe pneumonia’ after he travelled from Wuhan, the Chinese city at ground zero of the outbreak.
He had been a resident of Wuhan, where most cases have been, and travelled to the Philippines with a 38-year-old woman who was put into observation after his death.
After him, a 39-year-old man died in Hong Kong on February 5. The man had visited his 72-year-old mother in Wuhan, from whom he caught the illness.
Media in Hong Kong said the man was suffering from underlying health problems before he caught the illness, which is almost always mild.
People with long-term illnesses such as diabetes or heart disease, or with compromised immune systems, are the ones who are most at risk of dying because of the virus.
Health people can generally fend it off with only cold-like symptoms or without noticing they are ill at all.
But those whose bodies are weaker may develop a more serious infection in their lungs which can then progress to pneumonia, which is deadly.
The woman who died is thought to have been one of just 17 coronavirus cases diagnosed on the mainland of the country.
Ninety-three per cent of the 236 infections there have been diagnosed among passengers of a cruise ship which is being held in the water off Yokohoma.
The Diamond Princess has been docked at sea since February 3 after the first passengers tested positive for the virus.
Since then, a total of 219 have caught the illness.
Sick passengers have been taken off the boat and ferried to hospital by Japanese health workers, but the other holidaymakers – there are around 2,500 in total – are trapped on board and not allowed to leave.
British couple David and Sally Abel, from Northamptonshire, have a private balcony but are mostly confined to their cabin and have to wear masks and stay away from other passengers when they are let out for brief periods.
David and Sally Abel, from Northamptonshire, are among 2,500 passengers who have been stuck on the Diamond Princess off the Japanese coast since February 3
Passengers on board the Diamond Princess are not allowed off the ship until they have been confirmed to be virus free. The number of infected passengers has been rising by the day, to 219
Ambulances are pictured on a port near the city of Yokohoma, where the Diamond Princess is being held
The giant ship was carrying around 2,500 holidaymakers – more than 700 have been tested for the coronavirus
Asked how they were feeling, Mrs Abel yesterday told Good Morning Britain: ‘Wishing it was over. It’s getting harder. It’s a nightmare you just want to wake up from.’
But she said she and her husband are getting along okay, adding: ‘I must admit, we have got on pretty well. No arguments.’
What do we know about the coronavirus SARS-CoV-2?
Someone who is infected with the coronavirus can spread it with just a simple cough or a sneeze, scientists say.
At least 1,369 people with the virus are now confirmed to have died and more than 60,360 have been infected in at least 28 countries and regions. But experts predict the true number of people with the disease could be 100,000, or even as high as 350,000 in Wuhan alone, as they warn it may kill as many as two in 100 cases. Here’s what we know so far:
What is the coronavirus?
A coronavirus is a type of virus which can cause illness in animals and people. Viruses break into cells inside their host and use them to reproduce itself and disrupt the body’s normal functions. Coronaviruses are named after the Latin word ‘corona’, which means crown, because they are encased by a spiked shell which resembles a royal crown.
The coronavirus from Wuhan is one which has never been seen before this outbreak. It has been named SARS-CoV-2 by the International Committee on Taxonomy of Viruses. The name stands for Severe Acute Respiratory Syndrome coronavirus 2.
Experts say the bug, which has killed around one in 50 patients since the outbreak began in December, is a ‘sister’ of the SARS illness which hit China in 2002, so has been named after it.
The disease that the virus causes has been named COVID-19, which stands for coronavirus disease 2019.
Dr Helena Maier, from the Pirbright Institute, said: ‘Coronaviruses are a family of viruses that infect a wide range of different species including humans, cattle, pigs, chickens, dogs, cats and wild animals.
‘Until this new coronavirus was identified, there were only six different coronaviruses known to infect humans. Four of these cause a mild common cold-type illness, but since 2002 there has been the emergence of two new coronaviruses that can infect humans and result in more severe disease (Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses).
‘Coronaviruses are known to be able to occasionally jump from one species to another and that is what happened in the case of SARS, MERS and the new coronavirus. The animal origin of the new coronavirus is not yet known.’
The first human cases were publicly reported from the Chinese city of Wuhan, where approximately 11million people live, after medics first started publicly reporting infections on December 31.
By January 8, 59 suspected cases had been reported and seven people were in critical condition. Tests were developed for the new virus and recorded cases started to surge.
The first person died that week and, by January 16, two were dead and 41 cases were confirmed. The next day, scientists predicted that 1,700 people had become infected, possibly up to 7,000.
Just a week after that, there had been more than 800 confirmed cases and those same scientists estimated that some 4,000 – possibly 9,700 – were infected in Wuhan alone. By that point, 26 people had died.
By January 27, more than 2,800 people were confirmed to have been infected, 81 had died, and estimates of the total number of cases ranged from 100,000 to 350,000 in Wuhan alone.
By January 29, the number of deaths had risen to 132 and cases were in excess of 6,000.
By February 5, there were more than 24,000 cases and 492 deaths.
By February 11, this had risen to more than 43,000 cases and 1,000 deaths.
A change in the way cases are confirmed on February 13 – doctors decided to start using lung scans as a formal diagnosis, as well as laboratory tests – caused a spike in the number of cases, to more than 60,000 and to 1,369 deaths.
Where does the virus come from?
According to scientists, the virus has almost certainly come from bats. Coronaviruses in general tend to originate in animals – the similar SARS and MERS viruses are believed to have originated in civet cats and camels, respectively.
The first cases of COVID-19 came from people visiting or working in a live animal market in the city, which has since been closed down for investigation.
Although the market is officially a seafood market, other dead and living animals were being sold there, including wolf cubs, salamanders, snakes, peacocks, porcupines and camel meat.
A study by the Wuhan Institute of Virology, published in February 2020 in the scientific journal Nature, found that the genetic make-up virus samples found in patients in China is 96 per cent similar to a coronavirus they found in bats.
However, there were not many bats at the market so scientists say it was likely there was an animal which acted as a middle-man, contracting it from a bat before then transmitting it to a human. It has not yet been confirmed what type of animal this was.
Dr Michael Skinner, a virologist at Imperial College London, was not involved with the research but said: ‘The discovery definitely places the origin of nCoV in bats in China.
‘We still do not know whether another species served as an intermediate host to amplify the virus, and possibly even to bring it to the market, nor what species that host might have been.’
So far the fatalities are quite low. Why are health experts so worried about it?
Experts say the international community is concerned about the virus because so little is known about it and it appears to be spreading quickly.
It is similar to SARS, which infected 8,000 people and killed nearly 800 in an outbreak in Asia in 2003, in that it is a type of coronavirus which infects humans’ lungs.
Another reason for concern is that nobody has any immunity to the virus because they’ve never encountered it before. This means it may be able to cause more damage than viruses we come across often, like the flu or common cold.
Speaking at a briefing in January, Oxford University professor, Dr Peter Horby, said: ‘Novel viruses can spread much faster through the population than viruses which circulate all the time because we have no immunity to them.
‘Most seasonal flu viruses have a case fatality rate of less than one in 1,000 people. Here we’re talking about a virus where we don’t understand fully the severity spectrum but it’s possible the case fatality rate could be as high as two per cent.’
If the death rate is truly two per cent, that means two out of every 100 patients who get it will die.
‘My feeling is it’s lower,’ Dr Horby added. ‘We’re probably missing this iceberg of milder cases. But that’s the current circumstance we’re in.
‘Two per cent case fatality rate is comparable to the Spanish Flu pandemic in 1918 so it is a significant concern globally.’
How does the virus spread?
The illness can spread between people just through coughs and sneezes, making it an extremely contagious infection. And it may also spread even before someone has symptoms.
It is believed to travel in the saliva and even through water in the eyes, therefore close contact, kissing, and sharing cutlery or utensils are all risky.
Originally, people were thought to be catching it from a live animal market in Wuhan city. But cases soon began to emerge in people who had never been there, which forced medics to realise it was spreading from person to person.
There is now evidence that it can spread third hand – to someone from a person who caught it from another person.
What does the virus do to you? What are the symptoms?
Once someone has caught the COVID-19 virus it may take between two and 14 days, or even longer, for them to show any symptoms – but they may still be contagious during this time.
If and when they do become ill, typical signs include a runny nose, a cough, sore throat and a fever (high temperature). The vast majority of patients – at least 97 per cent, based on available data – will recover from these without any issues or medical help.
In a small group of patients, who seem mainly to be the elderly or those with long-term illnesses, it can lead to pneumonia. Pneumonia is an infection in which the insides of the lungs swell up and fill with fluid. It makes it increasingly difficult to breathe and, if left untreated, can be fatal and suffocate people.
What have genetic tests revealed about the virus?
Scientists in China have recorded the genetic sequences of around 19 strains of the virus and released them to experts working around the world.
This allows others to study them, develop tests and potentially look into treating the illness they cause.
Examinations have revealed the coronavirus did not change much – changing is known as mutating – much during the early stages of its spread.
However, the director-general of China’s Center for Disease Control and Prevention, Gao Fu, said the virus was mutating and adapting as it spread through people.
This means efforts to study the virus and to potentially control it may be made extra difficult because the virus might look different every time scientists analyse it.
More study may be able to reveal whether the virus first infected a small number of people then change and spread from them, or whether there were various versions of the virus coming from animals which have developed separately.
How dangerous is the virus?
The virus has so far killed 1,369 people out of a total of at least 60,367 officially confirmed cases – a death rate of around two per cent. This is a similar death rate to the Spanish Flu outbreak which, in 1918, went on to kill around 50million people.
However, experts say the true number of patients is likely considerably higher and therefore the death rate considerably lower. Imperial College London researchers estimate that there were 4,000 (up to 9,700) cases in Wuhan city alone up to January 18 – officially there were only 444 there to that date. If cases are in fact 100 times more common than the official figures, the virus may be far less dangerous than currently believed, but also far more widespread.
Experts say it is likely only the most seriously ill patients are seeking help and are therefore recorded – the vast majority will have only mild, cold-like symptoms. For those whose conditions do become more severe, there is a risk of developing pneumonia which can destroy the lungs and kill you.
Can the virus be cured?
The COVID-19 virus cannot currently be cured and it is proving difficult to contain.
Antibiotics do not work against viruses, so they are out of the question. Antiviral drugs can work, but the process of understanding a virus then developing and producing drugs to treat it would take years and huge amounts of money.
No vaccine exists for the coronavirus yet and it’s not likely one will be developed in time to be of any use in this outbreak, for similar reasons to the above.
The National Institutes of Health in the US, and Baylor University in Waco, Texas, say they are working on a vaccine based on what they know about coronaviruses in general, using information from the SARS outbreak. But this may take a year or more to develop, according to Pharmaceutical Technology.
Currently, governments and health authorities are working to contain the virus and to care for patients who are sick and stop them infecting other people.
People who catch the illness are being quarantined in hospitals, where their symptoms can be treated and they will be away from the uninfected public.
And airports around the world are putting in place screening measures such as having doctors on-site, taking people’s temperatures to check for fevers and using thermal screening to spot those who might be ill (infection causes a raised temperature).
However, it can take weeks for symptoms to appear, so there is only a small likelihood that patients will be spotted up in an airport.
Is this outbreak an epidemic or a pandemic?
The outbreak is an epidemic, which is when a disease takes hold of one community such as a country or region.
Although it has spread to dozens of countries, the outbreak is not yet classed as a pandemic, which is defined by the World Health Organization as the ‘worldwide spread of a new disease’.
The head of WHO’s global infectious hazard preparedness, Dr Sylvie Briand, said: ‘Currently we are not in a pandemic. We are at the phase where it is an epidemic with multiple foci, and we try to extinguish the transmission in each of these foci,’ the Guardian reported.
She said that most cases outside of Hubei had been ‘spillover’ from the epicentre, so the disease wasn’t actually spreading actively around the world.