Covid-19 was circulating in Italy as early as September 2019, a study by the National Cancer Institute of Milan has found.
Scientists made the discovery after checking blood samples that patients had given to take part in a cancer study, and found they contained antibodies to fight the virus.
Samples from 15 patients taken in September last year contained the antibodies, scientists said, meaning they had been exposed to the virus well before Italy’s first official coronavirus patient was diagnosed on February 21.
It also suggests that the virus had already spread from China to Europe even before the first cluster of infections was detected in Wuhan, in December 2019.
Mattia Maestri,Italy’s coronavirus Patient No. 1, whose case confirmed one of the world’s deadliest outbreaks was underway
China first reported that a ‘pneumonia of unknown cause’ was spreading in Wuhan on December 31, centered around a seafood market in the city.
But doctors including Li Wenliang – who would later die from the virus – had been warning for weeks that a new respiratory infection was spreading, in reports that were largely covered up.
Once news of the infections spread internationally, China moved to lock down several cities including Wuhan in an attempt to stop the infection spreading.
Authorities in Beijing subsequently admitted that the earliest known infection occurred December 8, but have never identified ‘patient zero’ – the first person to have caught the virus.
Because China has been unwilling or unable to identify that person, it is still not clear exactly where, when or how the first transmission occurred.
That has left significant questions marks over the early timeline of the virus, including how long it was spreading undetected before finally being identified.
Anecdotal evidence from China had suggested the disease was spreading in November, but the findings from Italy would change that timeline significantly.
Most researchers still agree that the disease originated in China – meaning it could have begun spreading there as early as summer 2019 before making its way to Italy.
The new findings, published by the National Cancer Institute’s (INT) scientific magazine Tumori Journal, show that 11.6 per cent of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020, had developed coronavirus antibodies well before February.
A further specific SARS-CoV-2 antibodies test was carried out by the University of Siena for the same research titled ‘Unexpected detection of SARS-CoV-2 antibodies in the pre-pandemic period in Italy’.
It showed that four cases dated back to the first week of October were also positive for antibodies neutralising the virus, meaning they had got infected in September, Giovanni Apolone, a co-author of the study, revealed.
Graph showing the number of new coronavirus deaths per day in Italy
Graph showing the number of new coronavirus cases per day in Italy
Mr Apolone said: ‘This is the main finding: people with no symptoms not only were positive after the serological tests but had also antibodies able to kill the virus.
‘It means that the new coronavirus can circulate among the population for long and with a low rate of lethality not because it is disappearing but only to surge again.’
Italian researchers said in March that they reported a higher than usual number of cases of severe pneumonia and flu in Lombardy in the last quarter of 2019 in a sign that the new coronavirus might have circulated earlier than previously thought.
The first known covid-19 case to have reached the UK was a cleaner from Essex who was not tested for the disease until after a 17-day stay in intensive care.
Joanne Rogers, 51, from Colchester, Essex, became ill with flu-like symptoms in late January and spent two weeks in bed at home with the mysterious illness before being rushed to hospital.
Joanne Rogers, 51, (left) from Colchester, Essex, and her daughter Lauren, 20. Ms Rogers became ill with flu-like symptoms in late January and was later rushed to hospital
At the time, February 15, covid-19 was still considered a far-flung virus, posing minimal risk to the UK public, with just nine people in the UK – Chinese students and those who had visited a French ski resort – being advised to isolate by Public Health England.
Sweden’s state epidemiologist Anders Tegnell revealed that the country likely had coronavirus cases as early as November last year.
He told Sweden’s TT news agency: ‘There wasn’t any spread [of infection] outside Wuhan until we saw it in Europe later.
‘But I think that you could find individual cases among Wuhan travellers who were there in November to December last year. That doesn’t sound at all strange, but rather very natural.’
Amirouche Hammar (pictured) revealed himself as the French patient who had coronavirus as early as December 27
The country’s first official coronavirus case was a woman in Jönköping who tested positive on January 31 after a trip to China. The woman has since recovered from the illness.
A doctor in France claimed the country saw its first coronavirus patient in December, weeks before its first officially recorded case.
Dr Yves Cohen, head of resuscitation at several hospitals in Ile-de-France, Paris, said new patient sample testing confirmed the virus was in France just after Christmas 2019.
His team revisited negative tests for coronavirus and flu of 24 patients who were admitted to hospital with respiratory symptoms in December and January – one of whom tested positive for covid-19.
Amirouche Hammar, 43, came forward following the revelation that an old flu sample of his from December 27 had tested positive for coronavirus – making him France’s ‘patient zero’.
The Algerian-born fish market worker had not travelled to China, and the result suggests the virus was spreading in well before January 24 when the country confirmed its first case.